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1. 成人の潰瘍性大腸炎治療に用いる生物学的製剤や低分子医薬品の用量およびモニタリングの概要overview of dosing and monitoring of biologic agents and small molecules for treating ulcerative colitis in adults [show details]
… response while on maintenance dosing and who are candidates for dose escalation, options include increasing the maintenance dose to 100 mg every four weeks,… chronic inflammatory disease of the colon characterized by bloody diarrhea. Biologic agents, including tumor necrosis factor-alpha inhibitors (eg, infliximab) and anti-integrin antibodies (vedolizumab), and …
2. 転移性脳腫瘍治療の概要overview of the treatment of brain metastases [show details]
…radiation and the tumor volume . As an example, multivariate analysis of results from the treatment of 80 patients with 126 lesions revealed that the minimum tumor dose was the only significant factor determining …
3. 成人のクローン病の治療：腫瘍壊死因子a阻害薬の用法・用量とモニタリングtreatment of crohn disease in adults dosing and monitoring of tumor necrosis factor alpha inhibitors [show details]
… on maintenance dosing can be managed by escalating the dose . Additionally, individuals who achieve an incomplete response can be managed in a similar fashion. Dose escalation can be… monoclonal antibodies directed against tumor necrosis factor (TNF)-alpha. The basis for their use in Crohn disease is that tumor necrosis factor (TNF)-alpha has…
4. 腫瘍崩壊症候群：予防および治療tumor lysis syndrome prevention and treatment [show details]
…as described below, a flat dose of 3 mg is commonly used. Doses are generally administered once daily, although if tumor lysis is massive, an increase to twice daily dosing may be needed. The average duration …
5. 転移性の高分化型胃腸系神経内分泌（カルチノイド）腫瘍：腫瘍増殖を管理する全身治療の選択肢metastatic well differentiated gastrointestinal neuroendocrine carcinoid tumors systemic therapy options to control tumor growth [show details]
… months of study entry, with visible tumor uptake on pretreatment SSTR scintigraphy . After the initial dose, additional treatment cycles were withheld if there was tumor progression or permanent toxicity; …