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1. 卵巣胚細胞腫瘍：病理学的特徴、疫学、臨床症状、診断ovarian germ cell tumors pathology epidemiology clinical manifestations and diagnosis [show details]
… liver, brain, bone, vagina, and other viscera. In contrast to gestational choriocarcinomas, those arising in the ovary are relatively chemoresistant. Polyembryoma is a malignant germ call neoplasm that …
2. 縦隔および後腹膜を含む性腺外胚細胞腫瘍extragonadal germ cell tumors involving the mediastinum and retroperitoneum [show details]
…primordial germ cells that fail to complete the normal migration along the urogenital ridge to the gonadal ridges during embryonal development. This may be due to an abnormality in the primordial germ cell itself… cells in bone marrow . Thus, leukemia may originate from a yolk sac, tumor-derived progenitor cell capable of undergoing hematopoietic differentiation with subsequent homing to the bone marrow.…
3. 精巣胚細胞腫瘍の疫学および危険因子epidemiology of and risk factors for testicular germ cell tumors [show details]
… nonseminomatous germ cell tumors (GCTs) are preceded by a premalignant condition germ cell neoplasia in situ (GCNIS). This was formerly called testicular intratubular germ cell neoplasia of… tumors that are often hormonally active . Some present with gynecomastia, rapid growth, and advanced bone age with markedly elevated levels of estradiol . Rarely, testicular metastases occur from a gastric …
4. 進行した精巣胚細胞腫瘍のリスク別の初期治療initial risk stratified treatment for advanced testicular germ cell tumors [show details]
… The risk stratification of advanced testicular germ cell tumors (GCTs) and initial management based on risk will be reviewed here.… primary site, with or without metastases. Metastases to organs other than the lungs (eg, liver, bone, or brain metastases). Tumor markers on day 1 of cycle 1 of chemotherapy (at least one must be above …
5. がんサバイバーや小児期に細胞障害性抗癌剤による治療を受けた患者の内分泌疾患endocrinopathies in cancer survivors and others exposed to cytotoxic therapies during childhood [show details]
…low bone mineral density (BMD) due to the following risk factors: Malignant infiltration of bone; Exposure to cranial or craniospinal irradiation; Chemotherapeutic agents that interfere with bone metabolism… testosterone production. One or both of these functions may be negatively impacted by cytotoxic treatment . Germ cells and Sertoli cells form the seminiferous tubules where spermatogenesis occurs; Leydig cells are …