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1. 直接作用型経口抗凝固剤を投与されている患者における出血のマネージメントmanagement of bleeding in patients receiving direct oral anticoagulants [show details]
… (including life-threatening) bleeding, we suggest administration of an antifibrinolytic agent (eg, tranexamic acid, epsilon-aminocaproic acid). The use of these agents may also be appropriate in individuals …
2. 成人の外傷患者に起きた中等度から重度の出血の初期マネージメントinitial management of moderate to severe hemorrhage in the adult trauma patient [show details]
…controlling bleeding following trauma. Antifibrinolytic agents for trauma and surgery are discussed separately. Tranexamic acid is the most well-studied antifibrinolytic agent in the setting of trauma and reduces …
3. 血栓溶解異常による血栓性および出血性疾患thrombotic and hemorrhagic disorders due to abnormal fibrinolysis [show details]
… plasma levels of fibrinolysis inhibitors such as PAI-1 can vary widely among healthy individuals. This variability complicates establishing elevated plasma levels of a fibrinolysis inhibitor as the definitive …
4. 外傷患者の凝固障害coagulopathy in trauma patients [show details]
… Diversion of thrombin to protein C activation may also reduce activation of thrombin-activatable fibrinolysis inhibitor (TAFI), further enhancing fibrinolytic activity . These mechanisms lead to the relative hyperfibrinolysis …
5. 止血の概要overview of hemostasis [show details]
…XI deficiency: increased fibrinolysis due to diminished activation of thrombin-activatable fibrinolysis inhibitor (TAFI) . The relatively high concentration of thrombin required within the clot for activation …