英: homology cloning
関: 相同性

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 生殖細胞または体細胞の相同組み換え修復欠損を認める進行性前立腺癌のマネージメントmanagement of advanced prostate cancer with germline or somatic homologous recombination repair deficiency [show details]
…and they are repaired by two major repair pathways: error-free (high-fidelity) homologous recombination and non-homologous (low fidelity) end-joining (NHEJ) . Defective DNA repair is a common hallmark of …
2. 遺伝学：用語集genetics glossary of terms [show details]
…uncoiling of packed chromatin (heterochromatin) into exposed DNA (euchromatin). Arising from a single clone, or cell. Examples include clonal selection of lymphocytes during immune development and clonal origin … The presence of two specified alleles at two linked loci on the same homologous chromosome (ie,…
3. ウィルソン病：疫学および病因wilson disease epidemiology and pathogenesis [show details]
… disorders are highly homologous, and identification of the gene for Menkes disease, ATP7A, led to the identification of the homologous gene for Wilson disease,… Using positional cloning and information deduced by homology with the Menkes disease gene (ATP7A),…
4. ビタミンKおよびその合成ならびにガンマカルボキシグルタミン酸の機能vitamin k and the synthesis and function of gamma carboxyglutamic acid [show details]
… Additional advances include purification and cloning of the vitamin K-dependent carboxylase ; determination… several proteins that contain Gla domains homologous to those of blood coagulation but of unknown function have been identified.…
5. 自己免疫性肝炎：病因autoimmune hepatitis pathogenesis [show details]
…that the pathogenesis of different forms of AIH may differ according to the autoantibody profile. Cloning and characterization of the SLA antigen revealed that it was a unique enzyme (possibly a UGA-suppressor … suggesting that they may arise from a specific immune stimulus such as a viral protein. However, no homologous virus-derived peptides could be identified in one report. Nevertheless, anti SLA/LP antibodies…