- 英
- two-step theory of carcinogenesis
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- 1. 頭頸部の扁平上皮癌化：分子学的および遺伝学的変化head and neck squamous cell carcinogenesis molecular and genetic alterations [show details]
… There was a strong correlation for hypermethylation between the two genes. The roles of these genes in HNSCC tumorigenesis are being actively studied.… and evaluated the DNA/RNA structural alterations, somatic mutations, genomic alterations by site, stage, human papillomavirus (HPV) status, molecular subtypes, and putative biomarkers. This study is the …
- 2. 乳房の発達および形態breast development and morphology [show details]
…The classic two-stage model of carcinogenesis further postulates that the altered genotype of the initiated cell is irreversible and that tumor progression, the second stage in carcinogenesis, depends upon …
- 3. 口腔異形成および頭頸部扁平上皮癌における化学予防およびスクリーニングchemoprevention and screening in oral dysplasia and squamous cell head and neck cancer [show details]
… subjects at different stages of carcinogenesis, unlike in the normal mucosa . COX-2 is also expressed in early and intermediate stages of carcinogenesis with progressively increased… for the development of invasive cancer is based on two factors: Field cancerization – Patients with carcinogen-related…
- 4. 大腸癌の分子遺伝学molecular genetics of colorectal cancer [show details]
… colorectal tumorigenesis . In keeping with this hypothesis, a large international study of 3583 CRCs found an increase in the frequency of TP53 mutations with advancing disease stage .… A "two-hit" model was proposed to explain the different clinical features of these two presentations The inherited…
- 5. 妊婦や授乳中の患者への画像診断diagnostic imaging in pregnant and nursing patients [show details]
… If injury to these cells occurs during a critical stage of organogenesis (primarily but not exclusively two to eight weeks after conception ),… or carcinogenesis are not observed during this stage of development ,…
Related Links
- イニシェーターとプロモーターによってがんが発生するという考えを「 発がんの二段階説 」という。
- 発がん二段階説に基づき開発されたモデル。 プロモーション期に被験物質を投与し、対照群との前がん 病変あるいは腫瘍発生の比較することにより、化学物質 の発がん修飾作用を検討する試験法である。 単一臓器二段階発がん性実験 ...
- 病気としてのガンになるまでには二つの段階があるといわれています（ 二段階発ガン説 ）。
★リンクテーブル★
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- 英
- step、stage、grade、phase
- 関
- 位相、局面、グレード、時期、ステージ、ステップ、相、程度、類別、段階的に実行する、フェーズ
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- 英
- carcinogenesis, oncogenesis
- 関
- 発癌物質
-carcinogenesis