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1. クッシング病の一次治療：経蝶形骨洞手術および下垂体照射primary therapy of cushings disease transsphenoidal surgery and pituitary irradiation [show details]
… to taper to a replacement dose, ideally within a few weeks. Transient, central diabetes insipidus is common and was reported at a rate of 22 percent in a single… disease are shown in the figure Primary therapy consists of transsphenoidal surgery or pituitary irradiation. Patients who fail this first approach can be treated either by repeat transsphenoidal surgery …
2. 頭頚部癌への根治的放射線治療：照射線量および線量分割の注意点definitive radiation therapy for head and neck cancer dose and fractionation considerations [show details]
… fractions per day to increase the total dose of radiation while maintaining a constant total treatment time and rate of late toxicity relative to conventional fractionation.… accelerated irradiation (seven days per week) or to conventional RT (five days per week), both to a total dose of 66 to 72 Gy . The five-year local tumor control and overall survival rates were better…
3. バンコマイシン：成人への非経口投与量、モニタリング、副作用vancomycin parenteral dosing monitoring and adverse effects in adults [show details]
… renal replacement therapy (CRRT), vancomycin clearance is relatively constant over the dosing interval and is closely related to the rate of ultrafiltrate/dialysate flow. Such patients may receive intermittent …
4. クッシング症候群の治療の概要overview of the treatment of cushings syndrome [show details]
… A dose of 150 to 200 mg of hydrocortisone (or dexamethasone equivalent if bilateral adrenalectomy is not done) may be administered by constant infusion or in divided doses intravenously… the cure rate approximates 70 to 80 percent, but late recurrences reduce the permanent cure rate to approximately 60 to 70 percent.… Pituitary irradiation may also decrease the occurrence of Nelson syndrome in patients not cured by irradiation for whom adrenalectomy becomes necessary,…
5. 肝疾患を有する患者における化学療法による肝毒性および用量調整：従来の細胞障害性薬物chemotherapy hepatotoxicity and dose modification in patients with liver disease conventional cytotoxic agents [show details]
… 35 patients with lymphoma received concurrent monthly vincristine and relatively low-dose liver irradiation (total dose, 15 to 25 Gy) . Ten of 35 patients developed severe hepatotoxicity (aspartate transaminase …