関: 健常ネフロン仮説

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1. 老化する腎臓the aging kidney [show details]
… Some studies with GFR measurements among healthy adults across the age spectrum have refuted this hypothesis. As an example, one study found that the 95^th percentile for GFR decreased by 38 mL/min/1 …changes occur with aging, including microanatomic changes, such as nephrosclerosis and a decline in nephron number, and macroanatomic changes, such as decreased kidney cortical volume and the development of renal …
2. 原発性（本態性）高血圧の病因における低出生体重の潜在的役割possible role of low birth weight in the pathogenesis of primary essential hypertension [show details]
…endothelin and nitric oxide), and low birth weight, frequently accompanying preeclampsia . Although this hypothesis is not universally accepted, the data supporting a role for low birth weight in the development … the association between low nephron number and the development of hypertension may not exist for African Americans.…
3. 成人における腎移植：移植片機能不全の危険因子kidney transplantation in adults risk factors for graft failure [show details]
… Several clues from clinical transplant databases support the hypothesis that inadequate renal mass,… transplant recipients who were screened for the presence of a 32-base-pair deletion for the CCR5 . The intact molecule is a cell surface receptor for several chemokines as well as the human immunodeficiency…
4. 高血圧性腎硬化症の臨床的特徴、診断および治療clinical features diagnosis and treatment of hypertensive nephrosclerosis [show details]
… trial, in which over 322,000 men were screened for possible entry, are compatible with the first hypothesis . A direct correlation was found between the initial blood pressure (measured on only one occasion)…maternal malnutrition, leading to low birth weight, impaired renal development, and a reduction in nephron number. The decrease in the number of nephrons results in compensatory hypertrophy in the nephrons that …
5. 慢性腎臓病の二次的要因と進行secondary factors and progression of chronic kidney disease [show details]
…approximately one-quarter of dialysis patients having relatives with ESKD . This is consistent with the hypothesis that common kidney diseases and progression to ESKD are influenced by the inheritance of specific…

「健常ネフロン仮説」

　　[★]

英: intact nephron hypothesis
同: 無損傷ネフロン仮説

「ネフロン」

　　[★]

英: nephron (Z)
ラ: nephronum
同: 腎単位
関: 皮質ネフロン、傍髄質ネフロン

図：SP.776
腎臓の機能的な単位
ネフロン = 腎小体 + 尿細管
ヒトのネフロンの数は片側の腎臓で約100万個といわれているが、ネフロンの数は個人差がある。
ネフロンの数は平均血圧と反比例している

皮質ネフロンと傍髄質ネフロンとの解剖的な違い

	皮質ネフロン	傍髄質ネフロン
腎小体	皮質に存在	髄質に近い皮質
直血管	×	○
ヘンレループの下行脚	○	○
ヘンレループの細い上行脚	×	○
ヘンレループの太い上行脚	○	○