同: ホットスポット

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1. 上皮成長因子受容体変異を有する進行非小細胞肺癌に対する全身療法systemic therapy for advanced non small cell lung cancer with an activating mutation in the epidermal growth factor receptor [show details]
… presence of specific activating mutations in the tyrosine kinase domain of the EGFR (exon 19 deletions, L858R point mutation in exon 21).… For patients with an EGFR mutation who progress on an EGFR TKI and are found to have a substitution of methionine for threonine at position 790 (T790M) mutation,…
2. プロトロンビンG20210A変異prothrombin g20210a mutation [show details]
… Diagnosis of the prothrombin G20210A mutation is straightforward because the mutation involves a single base change (point mutation) that can be detected by genetic testing,… The G20210A mutation results from a substitution of adenine (A) for guanine (G) at position 20210 in a non-coding region of…
3. 季節性インフルエンザウイルスにおける抗ウイルス薬耐性antiviral drug resistance among seasonal influenza viruses [show details]
… spontaneous mutations resulting in drug resistance in tissue culture is quite high, ranging from 1:1000 to 1:10,000 . Single-point mutations in the codons for amino acids at positions 26,… potentiate resistance conferred by the H275Y mutation. In H3N2 viruses, the most frequent mutations conferring resistance to oseltamivir are E119V and R292K,…
4. HIV薬剤耐性検査結果の解釈についてinterpretation of hiv drug resistance testing [show details]
… replication and the frequent introduction of mutations during each round of replication leads to the occurrence of randomly generated mutations,… maintain activity if there are no other additional NNRTI mutations. Similarly, a mutation at position Y143 can confer resistance to raltegravir…
5. 進行非小細胞肺癌に対する遺伝子型による個別治療personalized genotype directed therapy for advanced non small cell lung cancer [show details]
… spectrum of point mutations, gain-of-function mutations in PIK3CA were found in 4 percent of NSCLCs, including both adenocarcinoma and squamous cell histologies . No AKT mutations were observed… the switch is stuck in the on position all the time and is no longer subject to regulation. Oncogene addiction tends to make driver mutations good biomarkers for selecting…