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1. Approach to survivors of epithelial ovarian, fallopian tube, or peritoneal carcinomaapproach to survivors of epithelial ovarian fallopian tube or peritoneal carcinoma [show details]
… cancer susceptibility gene (BRCA) mutation sometimes express feelings of guilt due to transmission of the genetic mutation to their children or if they… platinum-based chemotherapy leads to long-lasting side effects in multiple domains that have been shown to decrease…
2. 上皮成長因子受容体変異を有する進行非小細胞肺癌に対する全身療法systemic therapy for advanced non small cell lung cancer with an activating mutation in the epidermal growth factor receptor [show details]
… of EGFR mutations ranged from 22 to 62 percent. Although EGFR mutations were more common in nonsmokers, the incidence still was 37 percent in regular smokers. The frequency of such mutations was higher… grade 3/4 toxicities between the agents in this study . In a phase IIB study comparing gefitinib and afatinib, disease outcomes were modestly improved with afatinib, although serious toxicities were…
3. 遺伝子治療、ゲノム編集、遺伝子発現抑制の概要overview of gene therapy gene editing and gene silencing [show details]
…editing in the germline may someday be used to "correct" a pathogenic mutation or to overcome the adverse effects of a pathogenic mutation (eg, by altering a downstream component of a pathway) and thus cure …
4. ドライバー変異のない進行非小細胞肺癌のマネージメント：免疫療法management of advanced non small cell lung cancer lacking a driver mutation immunotherapy [show details]
…receptor (EGFR) mutations because increased risk of pulmonary toxicity has been reported when these medications are used together . The approach to advanced NSCLC with driver mutations is discussed in …
5. 全身化学療法による眼の副作用ocular side effects of systemically administered chemotherapy [show details]
… kinase); all are approved for treatment of metastatic melanoma with a BRAF^V600 mutation. Several ocular toxicities are reported with all three agents: Dry eyes/conjunctivitis – A review of 568 patients …

Japanese Journal

B-11 セレン添加によるアマルガムの安全化に関する研究(第4報) : 細胞毒性と突然変異原性について

麻生田泉,粂井康宏,佐藤温重,奥野攻,中野毅,三浦維四
歯科材料・器械. Special issue, 日本歯科理工学会学術講演会講演集 3(特集A), 34-35, 1984-04
アマルガムより溶出する水銀の毒性は、微量のセレンを添加することにより抑制できるという点に着目し、0.05, 0.1, 0.2wt%セレン添加アマルガム(混汞比1:0.75)の溶出物のチャイニーズハムスター肺由来V-79細胞に対する細胞毒性および突然変異性を市販アマルガムのそれと比較した。市販アマルガム溶出物には細胞毒性、突然変異性が認められたが、セレン添加アマルガムではそれらが有意に抑制された。以 …
NAID 110002988562