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1. 1型糖尿病の病因pathogenesis of type 1 diabetes mellitus [show details]
… protein (IGRP); chromogranin A (ChgA); the insulin receptor; heat shock proteins; the antigens jun-B,… Autoimmune infiltration of the islets of Langerhans (insulitis) begins at approximately 50 days of age and clinical…
2. 1型糖尿病の予防prevention of type 1 diabetes mellitus [show details]
… serum C-peptide concentrations >0.1 nmol/L, DiaPep277, an immunomodulatory peptide derived from 60kDa heat shock protein, or placebo were given at zero, one, and six months. At 10 months, mean serum C-peptide… These observations suggest that insulin converts the insulitis from a destructive to a protective response .…
3. バセドウ病（グレーブス病）の発症機序pathogenesis of graves disease [show details]
… Bacterial heat shock proteins can elicit antibody and T cell responses, which may crossreact with host heat shock proteins. Heat shock protein 72 can be… obtained in an animal model of viral-induced autoimmune insulitis and in experimental autoimmune thyroiditis .…
4. 橋本病（慢性自己免疫性甲状腺炎）の病因pathogenesis of hashimotos thyroiditis chronic autoimmune thyroiditis [show details]
… both bacteria and humans have heat shock proteins. During the course of a bacterial infection, the host has an antibody and T cell response to the microbe heat shock protein .… This bystander effect hypothesis has support from studies in an animal model of insulitis and a model of experimental autoimmune thyroiditis .…
5. 青年や成人の労作性熱中症：疫学、体温調節、危険因子、および診断exertional heat illness in adolescents and adults epidemiology thermoregulation risk factors and diagnosis [show details]
… exercise-associated hyponatremia, nonexertional heat stroke, malignant hyperthermia and other causes of severe hyperthermia, and heat illness in children. Exertional heat illness (EHI) is an ever present danger …