UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 口腔異形成および頭頸部扁平上皮癌における化学予防およびスクリーニングchemoprevention and screening in oral dysplasia and squamous cell head and neck cancer [show details]
…head and neck cancer, since both premalignant and malignant lesions of the oral cavity overexpress COX-2 . In addition, administration of NSAIDs to laboratory animals prevents oral cancer development . …
2. 痘瘡ワクチンとしてのワクシニアウイルスvaccinia virus as the smallpox vaccine [show details]
…expressing foreign proteins may have future applications in vaccinating animals or people against infectious diseases or cancer . In recent years, many laboratories have been using highly attenuated poxviruses …
3. 世界アンチ・ドーピング機構が定めたホルモン製剤以外の禁止薬剤・禁止物質prohibited non hormonal performance enhancing drugs in sport [show details]
…using this drug. Preclinical trials were abandoned when high doses were linked to increased cancer rates in animals, and WADA has warned athletes of possible serious side effects. The drug continues to be …
4. リウマチ性疾患の男性患者の性腺機能と催奇形性に抗炎症薬や免疫抑制剤が及ぼす影響effects of antiinflammatory and immunosuppressive drugs on gonadal function and teratogenicity in men with rheumatic diseases [show details]
…with cancer results in significant sperm DNA damage . In animals, exposure to cyclophosphamide also induces genetic damage . In view of the indirect data from male animal models and men with cancer that…
5. 肝線維症の病因pathogenesis of hepatic fibrosis [show details]
…PDGF-C have hepatic fibrosis , the PDGF-C transgenic animals also develop hepatocellular carcinoma (HCC) , mimicking the progression from fibrosis to cancer that occurs in humans. Stellate cells can migrate …

Japanese Journal

乳癌治療の基礎研究を臨床へ―トランスレーショナルリサーチの実際―

藤森実,藤田知之,西村基 [他],越川佳代子,名倉直彌,天野純,谷口俊一郎
日本内分泌・甲状腺外科学会雑誌 29(4), 298-300, 2012
… longum</i>）菌を担癌動物に静脈内全身投与すると腫瘍組織でのみ特異的に集積・増殖することを見出し，Prodrug/Enzyme療法に用いられるCytosine Deaminase遺伝子を導入した組換え<i>B. …
NAID 130004600583