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1. A群レンサ球菌：病原性因子および発症機序group a streptococcus virulence factors and pathogenic mechanisms [show details]
… and/or complement regulatory proteins such as factor H, factor H-like protein,… or plasma, suggesting that these strains do in fact produce M protein . This could result from mutations within the emm gene, leading to production of novel M proteins that do not cross-react with standard … antistreptolysin O (ASO) titers may be falsely elevated because both cholesterol and anti-ASO antibody in serum neutralize SLO.…
2. 女性における乳癌リスクに影響を与える因子factors that modify breast cancer risk in women [show details]
… and environmental factors, although their association with breast cancer risk has not been clearly demonstrated. This topic will review risk factors that modify breast cancer… Specific genetic mutations that predispose to breast cancer are rare; only 5… The data regarding a possible protective effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on breast cancer risk are…
3. 手術不能な転移性大腸癌に対する全身化学療法：治療に関する推奨systemic chemotherapy for nonoperable metastatic colorectal cancer treatment recommendations [show details]
… patients whose tumors harbor a BRAF V600E mutation. Emerging data also suggest that the location of the primary tumor is another factor that influences the efficacy of anti-EGFR agents. Benefit for immunotherapy …
4. ドライバー変異のない進行非小細胞肺癌のマネージメント：免疫療法management of advanced non small cell lung cancer lacking a driver mutation immunotherapy [show details]
…growth factor receptor (EGFR) mutations because increased risk of pulmonary toxicity has been reported when these medications are used together . The approach to advanced NSCLC with driver mutations is discussed… activating epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK) alterations. Atezolizumab-based treatment – Atezolizumab is an anti-PD-L1 antibody engineered to…
5. 胃癌の危険因子risk factors for gastric cancer [show details]
… increase the risk of mutation while dietary antioxidants act as protective factors. Because some DNA damage can be self-corrected, H. pylori-related mutations only rarely lead to malignant… There may be a protective effect of nonsteroidal anti-inflammatory drug (NSAID) use.…