α-ケト酸
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- 1. 結核の免疫学immunology of tuberculosis [show details]
… keto-, and methoxy-mycolates . Alpha-mycolic acid has two cyclopropane rings, which are in the cis configuration, while the keto- and methoxymycolates have one ring in either cis or trans configuration …
- 2. リソソーム酸α-グルコシダーゼ欠損症（ポンペ病、糖原病II型、酸マルターゼ欠損症）lysosomal acid alpha glucosidase deficiency pompe disease glycogen storage disease ii acid maltase deficiency [show details]
… Acid alpha-glucosidase (GAA, also called acid maltase) deficiency (Pompe disease, MIM #232300) was the first identified lysosomal storage disease. It is also classified as glycogen storage disease type …
- 3. 胃酸分泌の生理学physiology of gastric acid secretion [show details]
… are not well understood. Transforming growth factor-alpha (TGF-alpha) is an autocrine factor that is present in parietal cells and inhibits gastric acid secretion . Peptide YY (PYY) is released postprandially …
- 4. 特定の脂肪酸酸化障害specific fatty acid oxidation disorders [show details]
… HADHB mutation analysis is often sufficient. A c.1528G>C mutation causing an amino acid substitution p.E510Q in the TFP-alpha subunit accounts for approximately 90 percent of all LCHADD. Treatment of LCHADD …
- 5. 遺伝性腎癌症候群hereditary kidney cancer syndromes [show details]
… Inherited mutations involving enzymes of the tricarboxylic acid (Krebs) cycle are associated with aggressive forms of… and pseudohypoxia . One study showed that an antioxidant response element-controlled gene, the aldo-keto reductase family 1 member B10 (AKR1B10), is upregulated in FH knockdown and FH null cell lines . Other … result in the generation of reactive oxygen species and stabilization of hypoxia-inducible factor 1 alpha (HIF1A), which is necessary for the generation of pseudohypoxia . HLRCC is transmitted in an autosomal…
Japanese Journal
- Cationized liposomal keto-mycolic acids isolated from Mycobacterium bovis bacillus Calmette-Guérin induce antitumor immunity in a syngeneic murine bladder cancer model
- 木村 友和
- PLOS ONE 14(1), e0209196, 2019-02
- … Mycolic acid (MA), the most abundant lipid of the BCG cell wall, is suspected to be one of the essential active components of this immunogenicity. … Here, we developed cationic liposomes incorporating three subclasses (α, keto, and methoxy) of MA purified separately from BCG, using the dendron-bearing lipid D22. …
- NAID 120006582988
- Physiological and pathological roles of branched-chain amino acids in the regulation of protein and energy metabolism and neurological functions
- Shimomura Yoshiharu,Kitaura Yasuyuki
- Pharmacological Research (133), 215-217, 2018-07
- ファイル公開：2019-07-01
- NAID 120006554495
- Analysis of Branched-Chain Keto Acids in Cell Extracts by HPLC-Fluorescence Detection
- HATTORI Ayuna,ITO Takahiro,TSUNODA Makoto
- CHROMATOGRAPHY 38(3), 129-133, 2017
- … <p>An analytical method for quantifying branched-chain keto acids (BCKAs) - namely α-keto-isovaleric acid (KIV), α-keto-isocaproic acid (KIC), and α-keto-β-methylvaleric acid (KMV) - in cell extracts was developed and applied to a human chronic myelogenous leukemia cell line. …
- NAID 130007040468
Related Links
- カルボニル基 C＝Oとカルボキシル基－COOHの両方をもつ化合物の総称。ケトン酸ketonic acid，ケトカルボン酸keto‐carboxylic acidともいう。両官能基が直接結合しているものをα‐ケト酸といい，これらの相対位置が離れるにしたがってβ ...
- The greener characteristic of the coproduct formed in reactions using α-keto acid (only CO2), together with its versatility as a building block in catalytic organic synthesis, accredit it as a candidate to green acylating agent, an ...
- Summary: The branched-chain alpha-keto acid (BCAA) dehydrogenase (BCKD) complex is an innter mitochondrial enzyme complex that catalyzes the second major step in the catabolism of the branched-chain amino acids leucine ...
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- 英
- α-keto acid
- 関
- ケト酸
- 同
- 2-オキソ酸
構造式 R-CO-COOH
- (カルボン酸の場合、カルボキシ基の炭素原子に近い方の炭素からα、β、γとつけていく。だからα位にカルボニル基(carbonyl, keto)がある酸という命名 )
生体内では、不要なアミノ酸の分解の際に生成する。
R-CH(NH2)-COOH + O= → R-CO-COOH + -NH3+
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ケト酸
- 関
- ketoacid