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1. 上皮成長因子受容体（EGFR）阻害薬およびMEK阻害薬の投与に続発するざ瘡様発疹acneiform eruption secondary to epidermal growth factor receptor egfr and mek inhibitors [show details]
… a sun protection factor (SPF) ≥30. Two small studies have evaluated the efficacy of an ointment containing recombinant epidermal growth factor (EGF) : In an open-label study,… and Janus kinase/signal transducer and activator of transcription (JAK/STAT).… face and vehicle foam on the other side before the initiation of EGFR inhibitor therapy .…
2. ミトコンドリアの構造、機能、および遺伝学mitochondrial structure function and genetics [show details]
… respectively) Translation initiation, elongation and release factors; Ribosomal protein assembly factors; mRNA polyadenylation factors; Translational activators;… mitochondrial DAMPs include mitochondrial DNA, mitochondrial ATP, N-formyl peptides, and mitochondrial transcription factor A. Mitochondria can activate the NLRP3 inflammasome (a multimeric complex which can activate …
3. 赤血球産生調節regulation of erythropoiesis [show details]
…require stabilization and activation of specific transcription factors . One of these is the heterodimeric transcription factor complex hypoxia-inducible factor (HIF-1), comprising both HIF-1-alpha and HIF-1-beta …
4. サラセミア症候群の分子遺伝学的特性molecular genetics of the thalassemia syndromes [show details]
…RNA polymerase and the initiation of transcription. Enhancer and silencer elements stimulate or repress transcriptional activity, depending on the array of transcription factors to which they are bound …
5. 健常者および患者における胎児性ヘモグロビン（ヘモグロビンF）fetal hemoglobin hemoglobin f in health and disease [show details]
… In addition to multiple mechanisms of transcriptional control, HbF synthesis was induced at the level of translation by phosphorylation of the initiation factor eIF2alpha (HRI) . EIF2AK1 phosphorylates …