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1. ヘム色素誘発性急性腎障害の臨床的特徴および診断clinical features and diagnosis of heme pigment induced acute kidney injury [show details]
… and diagnosis of heme pigment-induced AKI due to nontraumatic rhabdomyolysis and to hemolysis will be reviewed here. Prevention and treatment of heme pigment-induced AKI,… filtered due both to its large size (mol wt 69,000 of tetramer and 34,000 of dimer) and protein binding to haptoglobin. As a result, hemoglobinuria requires a relatively high plasma hemoglobin concentration …
2. ビリルビン代謝bilirubin metabolism [show details]
… increases after albumin infusion because of transfer of the pigment from tissue stores to the intravascular space. Several other ligands bind to albumin at the same site as bilirubin, including sulfonamides …
3. 遺伝性球状赤血球症hereditary spherocytosis [show details]
… following: EMA binding – If specialized testing is indicated, EMA binding is our preferred test. EMA (eosin-5-maleimide) is an eosin-based fluorescent dye that binds to RBC membrane… spherocytes on the blood smear , or the individual may be symptomatic from anemia, splenomegaly, pigment gallstones, or jaundice. Jaundice due to severe hemolysis is less common after the newborn period …
4. 遺伝性楕円赤血球症と関連疾患hereditary elliptocytosis and related disorders [show details]
… 4.1 binds to the spectrin-actin cytoskeleton via a 10 kD internal domain and contributes to membrane stability via its spectrin-actin binding .… hemolysis may have associated findings such as jaundice (including neonatal jaundice), splenomegaly, or pigment gallstones. Common HE is usually asymptomatic in heterozygotes, with no or only minimal signs of …
5. ヘム色素誘発性急性腎障害 (横紋筋融解症を含む）の予防および治療prevention and treatment of heme pigment induced acute kidney injury including rhabdomyolysis [show details]
…is caused by the nonprotein heme pigment that is released from either myoglobin or hemoglobin and is toxic to the kidney. The prevention and treatment of heme pigment-induced AKI due to nontraumatic rhabdomyolysis …