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1. 1型糖尿病の病因pathogenesis of type 1 diabetes mellitus [show details]
… accelerated islet destruction and a higher requirement for exogenous insulin during the second year of clinical disease . A few patients from Japan without obvious evidence of islet autoimmunity have… destruction of the insulin-producing beta cells in the islets of Langerhans .… although inflammation (eg, interleukin-1 mediated) may play a role in islet beta cell loss in both types .…
2. 先天性免疫異常症/原発性免疫不全症患者における自己免疫autoimmunity in patients with inborn errors of immunity primary immunodeficiency [show details]
…complications exist, compared with patients with the same IEI without autoimmunity/inflammation; and pre-existing autoimmunity/inflammation adversely affects the outcomes of hematopoietic stem cell transplantation …
3. 間質性肺疾患の診断における気管支肺胞洗浄検査の役割role of bronchoalveolar lavage in diagnosis of interstitial lung disease [show details]
… pulmonary Langerhans cell histiocytosis, drug-induced pneumonitis, coccidioidal infection, and connective tissue diseases affecting the lungs Idiopathic… A study that measured calgranulin B (small calcium-binding protein mainly involved in chronic inflammation, particularly neutrophil activity) and Krebs von den Lungen 6 (KL-6) in BAL fluid of patients …
4. 未分化型の全身性リウマチ性（結合組織）疾患およびオーバーラップ症候群undifferentiated systemic rheumatic connective tissue diseases and overlap syndromes [show details]
… historically described as having "collagen" or "connective tissue" diseases, since they shared similar clinical and pathologic features of widespread inflammation . Subsequently, these patients have been considered …
5. 原発性免疫不全症の肺合併症pulmonary complications of primary immunodeficiencies [show details]
…peribronchiolar lymphocytic inflammation . Organizing pneumonia is also a prominent finding in addition to the typical histopathologic features of nodular peribronchial inflammation with mature… (IL)-12/IL-23/interferon (IFN)-gamma signaling or the presence of autoantibodies to IFN-gamma.…

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下垂体細胞の好塩基性細胞に属

★リンクテーブル★

関連記事	「免疫」「膵島」「炎」「自己免疫」「自己」

「免疫」

　　[★]

英: immunity, immune
関: 免疫系

免疫の種類 (PT.246-251)

液性免疫(humoral immunity)と細胞性免疫がある。

	主に関与するリンパ球	働き	リンパ節での局在
細胞免疫	T細胞	(1)免疫の活性化	傍皮質
		(2)抗原を有する細胞への攻撃
液性免疫	B細胞	抗体産生	皮質

T細胞の種類

細胞の種類	補レセプター	抗原を提示する細胞	MHC抗原
キラーT細胞(Tc)	CD8	抗原提示細胞	MHCクラスI
ヘルパーT細胞(Th)	CD4	全ての細胞	MHCクラスII

ヘルパーT細胞の種類

T細胞	関連する因子	産生する物質	機能
Th1	IL-12 　増殖	IL-2,IFN-γなど	細胞性免疫を促進' 　(1)キラーT細胞、NK細胞、マクロファージを活性化　(2)遅延型過敏反応により自己免疫疾患に関与
Th2	IL-4 　Th→Th2	IL-4,IL-5,IL-6,IL-10など	液性免疫を促進' 　(1)B細胞、好酸球、肥満細胞に作用。　(2)即時型アレルギーに関与