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1. 組織に依存しないがん治療：固形がんにおけるDNAミスマッチ修復の欠損、腫瘍変異量および免疫チェックポイント遮断への応答tissue agnostic cancer therapy dna mismatch repair deficiency tumor mutational burden and response to immune checkpoint blockade in solid tumors [show details]
… TMB, with 97 percent having TMB ≥10 mut/Mb Although most MSI-H tumors are TMB-high, not all TMB-high cases are MSI-H. These mutations code for mutant proteins, which, like other cell proteins, are recycled …
2. 非膵島細胞腫瘍性低血糖nonislet cell tumor hypoglycemia [show details]
… Hypoglycemia can be caused by several tumors, including islet and nonislet tumors. Nonislet cell tumor hypoglycemia (NICTH) is a rare but serious complication of malignancy . The most common cause of …
3. 脳腫瘍による頭痛brain tumor headache [show details]
… features of brain tumor headache are generally nonspecific and vary widely with tumor location, size, and rate of growth . The headache is usually bilateral but can be on the side of the tumor . Supratentorial …
4. 甲状腺結節および非髄様甲状腺癌におけるオンコジーンおよび腫瘍抑制遺伝子oncogenes and tumor suppressor genes in thyroid nodules and nonmedullary thyroid cancer [show details]
… Autonomously functioning thyroid nodules are benign tumors that produce thyroid hormone. Many of these tumors are caused by somatic mutations in genes that code for the thyroid-stimulating hormone (TSH) receptor …
5. ウィルムス腫瘍の治療および予後treatment and prognosis of wilms tumor [show details]
… diagnosis are associated with an increased risk of tumor recurrence or death and include : Tumor histology; Tumor stage; Molecular and genetic markers (eg, loss of heterozygosity [LOH] at chromosome 16q, 1p …