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1. 脳脊髄液：疾患状態における検査の生理学および有用性cerebrospinal fluid physiology and utility of an examination in disease states [show details]
… Cerebrospinal fluid pressure – The normal cerebrospinal fluid (CSF) pressure is 6 to 20 cmH₂O; patients with obesity may have CSF pressures up to 25 cmH₂O.… The CSF is propelled along the neuroaxis by a cranio-caudal pulsatile wave induced by flow in the cerebral arteries and by the… When assessing the potential effect of CSF bleeding on an elevated CSF protein concentration,…
2. 下行大動脈手術の麻酔と麻酔管理anesthesia for descending thoracic aortic surgery [show details]
… as well as with neuromonitoring to assess the effects of these interventions . Guidelines for intrathecal catheter management, CSF pressure monitoring,… which generates waves that travel down the corticospinal tract to the nerve root and the peripheral nerve,…
3. 成人の急性細菌性髄膜炎の臨床的特徴と診断clinical features and diagnosis of acute bacterial meningitis in adults [show details]
…2009 to remove impaired mental status as a contraindication to LP without prior CT scan, and the effect of this change was evaluated in a retrospective study using the Swedish quality registry . After …
4. 自発性頭蓋内圧低下症：病態生理、臨床的特徴および診断spontaneous intracranial hypotension pathophysiology clinical features and diagnosis [show details]
… meta-analysis of 14 studies that included 406 patients found spinal MRI was abnormal in 48 percent (effect size 95% CI 0.3-0.6) . Imaging features on MRI of the spine in patients with spontaneous intracranial … patients with normal CSF pressure have been described who have clinical and radiographic features typical of orthostatic headache . In this paradigm, the CSF pressures,…
5. 特発性頭蓋内圧亢進症（偽脳腫瘍）：臨床的特徴および診断idiopathic intracranial hypertension pseudotumor cerebri clinical features and diagnosis [show details]
… This reflects a nonlocalizing effect of elevated intracranial pressure on the sixth nerve,… CSF pressures can vary, and a normal reading in a patient with IIH may reflect a spurious low reading for that patient as CSF pressure fluctuates throughout the day.…

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関連記事	「脳脊髄液」「脊髄」「脳脊髄液圧」「脳脊髄」「髄液圧」

「脳脊髄液」

　　[★]

英: cerebrospinal fluid (KH), CSF
同: 髄液、髄液圧

一日あたりの産生量：500-700ml

成人での総量：100-150ml　採取するときはせいぜい10-15ml程度にとどめたほうがよい

脊椎管内：20-30ml
脊髄の下端：約5ml

性状など

SCN.113

	正常	備考
脊髄圧	100-180 mmH2O	＞200mmH2Oで頭蓋内圧亢進
外観	水様透明
比重	1.005-1.009
細胞数	0-5mm3
蛋白	15-45mg/dl	炎症、頭蓋内出血、腫瘍、外傷、中毒、MSなどでみられる
グルコース	50-75mg/dl	血糖値の60-80%
クロール	120-130mEq/l	結核性髄膜炎の初期で低下

多発性硬化症とギラン・バレー症候群の比較

多発性硬化症：細胞・蛋白・IgG・ミエリン塩基性蛋白は軽度から中等度上昇。電気泳動：60-80%でオリゴクローナルIgGバンド、ミエリンベーシック蛋白質陽性。
ギラン・バレー症候群：蛋白細胞解離(蛋白は上昇するが細胞は正常レベル。発症から1週間後の患者の80-90%の患者で見られる。近位神経根のレベルで血液神経関門の透過性が亢進したことによるのかもしれない)。