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1. チオプリン系薬剤：炎症性腸疾患の成人に対する治療前検査および治療薬モニタリングへのアプローチthiopurines pretreatment testing and approach to therapeutic drug monitoring for adults with inflammatory bowel disease [show details]
… Screening for genetic factors that influence drug metabolism is discussed in more detail separately.… allowing more drug to be converted to 6-TG . Dose-optimization or toxicity-avoidance strategies based upon drug metabolite monitoring have been associated with improved clinical outcomes.…
2. 中度と重度の急性外傷性脳損傷のマネージメントmanagement of acute moderate and severe traumatic brain injury [show details]
…either agent to improve outcomes such as mortality or functional recovery. The majority of studies do suggest improved ICP control with hypertonic saline , along with possible improvements in cerebral perfusion… measurement of cerebral physiologic and metabolic parameters related to oxygen delivery, cerebral blood flow (CBF), and metabolism, with the goal of improving the detection and…
3. HIV感染症の治療に用いる抗レトロウイルス薬の概要overview of antiretroviral agents used to treat hiv [show details]
… to increase trough plasma drug concentrations, increase drug half-lives, and increase maximum plasma concentrations (C_MAX). This improves the potency of the antiviral agent and enables lower and less …
4. 薬物アレルギー患者へのアプローチan approach to the patient with drug allergy [show details]
… differences in drug metabolism are a risk factor for drug allergy. Although some initial studies suggested that slow acetylation or low glutathione levels might influence the frequency of drug hypersensitivity …
5. 薬理ゲノム学の概要overview of pharmacogenomics [show details]
… factors can influence the response to pharmacologic agents : Effect on drug pharmacokinetics, which may include the drug absorption, distribution, metabolism, and/or elimination; Effects on pharmacodynamics …