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1. 止血の概要overview of hemostasis [show details]
…lysis and tissue remodeling. Abnormal bleeding can result from diminished thrombin generation (eg, due to factor VIII deficiency) or enhanced clot lysis (eg, due to alpha-2-antiplasmin deficiency). Conversely …
2. 組織に依存しないがん治療：固形がんにおけるDNAミスマッチ修復の欠損、腫瘍変異量および免疫チェックポイント遮断への応答tissue agnostic cancer therapy dna mismatch repair deficiency tumor mutational burden and response to immune checkpoint blockade in solid tumors [show details]
… length of a microsatellite in normal tissue compared with its length in the same patient tumor tissue.… tumor is said to have high levels of microsatellite instability (MSI-H), which reflects underlying deficiency in mismatch repair capability. As expected, an inability to repair DNA damage results in the …
3. 出血症状を有する小児に対するアプローチapproach to the child with bleeding symptoms [show details]
… possible diagnoses include some cases of hemophilia, factor XIII deficiency, platelet function disorders, vascular anomalies, connective tissue disorders, and fibrinolytic disorders. In addition, some patients …
4. ビタミンAの概要overview of vitamin a [show details]
… these tissues on retinoic acid. Normal fetal development of the eye also requires adequate vitamin A intake and stores . Studies in vitamin A-depleted animals show abnormal fetal eye tissue development… Vitamin A deficiency is rarely seen in the United States and other resource-rich countries. However, fat-soluble vitamin deficiencies,…
5. ホスホグリセリン酸キナーゼ欠損症およびホスホグリセリン酸ムターゼ欠損症phosphoglycerate kinase deficiency and phosphoglycerate mutase deficiency [show details]
…genetic counseling . The age of onset for PGK deficiency is variable. PGK deficiency may present as either isolated or associated involvement of three tissues (erythrocytes, the central nervous system [CNS] …