英: corticomedullary osmotic gradient

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1. 水分バランス異常（低ナトリウム血症および高ナトリウム血症）およびナトリウムバランス異常（循環血液量減少および浮腫）の一般原則general principles of disorders of water balance hyponatremia and hypernatremia and sodium balance hypovolemia and edema [show details]
… the luminal membranes of principal cells in the cortical and medullary collecting tubules ,… associated with a reduction in plasma osmolality and tonicity . This initially creates an osmotic gradient that favors water movement from the ECF into cells and the brain.…
2. 多尿患者の評価evaluation of patients with polyuria [show details]
… polyuria: partial wash out the medullary interstitial gradient and downregulation of ADH release . A properly performed test in which ADH is not given until the plasma osmolality exceeds 295 mosmol/kg (and …
3. 常染色体優性尿細管間質性腎臓病（髄質嚢胞性腎疾患）autosomal dominant tubulointerstitial kidney disease medullary cystic kidney disease [show details]
…were bilateral in approximately 60 percent of cases. Most cysts were corticomedullary or medullary, but cortical cysts were also seen. The diagnosis of ADTKD-MUC1 is suspected based upon clinical manifestations …
4. 嚢胞性腎疾患の胎児超音波診断prenatal sonographic diagnosis of cystic renal disease [show details]
… presentation of ARPKD with increased cortical echogenicity, decreased corticomedullary differentiation, multiple medullary cysts,… collecting ducts where they contribute to the flow of the urine and, indirectly, to its composition and osmolality. Ciliopathies share clinical features with a considerable genetic and phenotypic overlap. They …
5. 利尿剤の作用機序mechanism of action of diuretics [show details]
… They act in the medullary and cortical aspects of the thick ascending limb,… directly increasing the plasma osmolality. In this setting, water movement out of the cells down an osmotic gradient will lower the plasma sodium concentration by dilution .…