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1. 移植片対宿主病（GVHD）の皮膚症状cutaneous manifestations of graft versus host disease gvhd [show details]
…documented in a case report . Patients should be educated regarding early signs of skin sclerosis, such as skin tightness, edema, and reduced range of motion, and should be instructed to seek care if these …
2. 若年性全身性硬化症（強皮症）：分類、臨床症状、診断juvenile systemic sclerosis scleroderma classification clinical manifestations and diagnosis [show details]
…with complaints of visceral organ involvement. Rather, the main complaints are related to RP and skin tightness and sometimes weight loss or poor growth . Direct questioning is often required to elicit a …
3. 下肢慢性静脈疾患の概要overview of lower extremity chronic venous disease [show details]
… of the venous system. Symptoms or findings include pain, leg heaviness, aching, swelling, skin dryness, tightness, itching, irritation, and muscle cramps. The clinical evaluation of the patient with lower …
4. 若年性全身性硬化症（強皮症）：評価および治療のアプローチjuvenile systemic sclerosis scleroderma assessment and approaches to treatment [show details]
…treatment with rituximab in combination with cyclophosphamide resulted in subjective improvement in skin tightness and sense of well-being, but no changes in diffusing capacity of the lungs for carbon monoxide …
5. 成人における斑状強皮症（限局性強皮症）：マネージメントmorphea localized scleroderma in adults management [show details]
… methotrexate (15 to 25 mg per week) led to improvement in both the modified skin score and patient-reported feelings of tightness and itching . However, three patients discontinued the study due to adverse …