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1. 頭頸部の扁平上皮癌化：分子学的および遺伝学的変化head and neck squamous cell carcinogenesis molecular and genetic alterations [show details]
…mutagenic progression, called multistep carcinogenesis, parallels the genetic model of colorectal carcinogenesis . Evidence for a mutational progression in tumorigenesis of head and neck squamous cell …
2. 大腸癌の分子遺伝学molecular genetics of colorectal cancer [show details]
…clonal nature of tumors is a critical feature of the somatic mutation/clonal evolution theory of human carcinogenesis. According to this model, the growth advantage acquired by a single mutated cell allows …
3. 口腔異形成および頭頸部扁平上皮癌における化学予防およびスクリーニングchemoprevention and screening in oral dysplasia and squamous cell head and neck cancer [show details]
…mucosa of subjects at different stages of carcinogenesis, unlike in the normal mucosa . COX-2 is also expressed in early and intermediate stages of carcinogenesis with progressively increased expression …
4. 急性骨髄性白血病の分子遺伝学molecular genetics of acute myeloid leukemia [show details]
… These animal models have also demonstrated the multistage nature of the evolution of leukemia.…component of the fusion gene and thus dissect the motifs within these genes that are critical to tumorigenesis. The fusion of nucleophosmin (NPM) to ALK is a frequent recurring abnormality in anaplastic large …
5. ヘリコバクターピロリ菌感染と消化管悪性腫瘍の関連性association between helicobacter pylori infection and gastrointestinal malignancy [show details]
…feature of H. pylori-induced duodenal ulcer is unclear. One theory is that atrophic gastritis, which is an early step in gastric carcinogenesis , occurs with H. pylori-related gastric ulcers but not duodenal …