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1. 成人男性における細胞傷害性薬物が性腺機能に及ぼす影響effects of cytotoxic agents on gonadal function in adult men [show details]
…disease (mean total dose 395 mg/kg), the incidence of gonadal dysfunction was 80 percent in men who received cumulative doses in excess of 300 mg/kg . Cumulative cyclophosphamide doses of 6 to 10 g are likely …
2. リウマチ性疾患の男性患者の性腺機能と催奇形性に抗炎症薬や免疫抑制剤が及ぼす影響effects of antiinflammatory and immunosuppressive drugs on gonadal function and teratogenicity in men with rheumatic diseases [show details]
…magnitude of the effect on sperm production is drug-specific and dose- and duration-dependent. Additional factors that may influence gonadal function in patients receiving these medications include effects …
3. 放射性ヨウ素による甲状腺機能亢進症の治療radioiodine in the treatment of hyperthyroidism [show details]
…to term. Birth defects do not appear to be more common in women treated with radioiodine . The gonadal dose is approximately three rad, similar to that for hysterosalpingography or a barium enema . The …
4. 思春期早発症の治療treatment of precocious puberty [show details]
…suppression of the pituitary-gonadal axis . If this testing shows incomplete suppression of the pituitary-gonadal axis, the GnRH agonist dose should be increased or the interval between doses decreased. Within …
5. 小児癌患者の骨に関する問題bone problems in childhood cancer patients [show details]
… (eg, alkylating agents) . Gonadal dysfunction may develop after radiation doses to the ovaries of 10 Gy or more in prepubertal age and 5 Gy or more during puberty. Radiation doses of 5 Gy to the testes may …