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1. 自然免疫系の概要an overview of the innate immune system [show details]
… comprise the innate immune system, the functional differences between innate and acquired immune responses, and the mechanisms by which the two systems interact. Disorders of innate immunity… "alarmins" that are released from host cells as a result of infection or tissue injury . Once released extracellularly, alarmins can activate innate immune cells to release proinflammatory…
2. 血管浮腫の概要：病因と原因an overview of angioedema pathogenesis and causes [show details]
…subdivided into three groups, depending on the underlying mechanism : Mast cell-mediated etiologies, in which angioedema results from release of mast cell-derived mediators that increase vascular permeability …
3. アレルギー性接触皮膚炎の基本的機序および病態生理basic mechanisms and pathophysiology of allergic contact dermatitis [show details]
…immune mechanisms and pathophysiology of ACD. The clinical manifestations, diagnosis, and management of ACD are discussed separately. The understanding of the cellular and molecular pathogenesis of allergic… Innate immune cells (dendritic cells [DC], mast cells, natural killer [NK], NKT-cells) play a critical role in allergic contact dermatitis (ACD) Innate lymphoid cells… released by infiltrating CD8⁺ and CD4⁺ T cells, in particular IFN-gamma, stimulate keratinocytes to release cytokines and chemokines,…
4. 尋常性乾癬の病態生理pathophysiology of plaque psoriasis [show details]
… The cellular components of the innate immune system that have been linked to the pathophysiology of psoriasis include the professional… and the cytokines released from immune cells likely contribute to the initiation…
5. アレルギー性疾患へのアレルゲン免疫療法：治療法の作用機序allergen immunotherapy for allergic disease therapeutic mechanisms [show details]
… mediators due to repetitive stimulation and release (ie, tachyphylaxis) . This mechanism of early desensitization of Fc-epsilon-RI-bearing… T and B cells (Tregs and Bregs) and suppression of allergen-specific effector T cell subsets and innate lymphoid cells. Decreases in tissue mast cells and eosinophils, which is accompanied by a decrease …