UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 甲状腺刺激ホルモンおよび甲状腺刺激ホルモン放出ホルモンに対する抵抗性resistance to thyrotropin and thyrotropin releasing hormone [show details]
… Several general mechanisms have been identified: Impaired biologic activity of… post-transcriptional modifications that result in production of an abnormal hormone molecule.… The syndromes of resistance to thyrotropin (TSH) and resistance to thyrotropin-releasing hormone (TRH) will be discussed here.…
2. 妊娠可能年齢の女性に生じる不正子宮出血：用語とPALM-COEIN原因分類基準abnormal uterine bleeding in reproductive age women terminology and palm coein etiology classification [show details]
… Abnormal uterine bleeding (AUB) in nonpregnant reproductive-age women is a common gynecologic symptom.… scientific and diagnostic advances have now led to a better understanding of underlying mechanisms of these symptoms,… agents may include progestin-based contraceptive agents with or without estrogen, gonadotropin-releasing hormone agonists, aromatase inhibitors, and selective estrogen or progesterone receptor modulators …
3. タモキシフェンによるホルモン療法を受ける女性の不正子宮出血と子宮の病理abnormal uterine bleeding and uterine pathology in women on tamoxifen therapy [show details]
…therefore up-regulate gonadotropin-releasing hormone agonist secretion from the hypothalamus; however, the mechanisms of action are complex and data in humans are limited . Abnormal uterine bleeding (AUB) is common …
4. 機能性視床下部性無月経：病態生理と臨床症状functional hypothalamic amenorrhea pathophysiology and clinical manifestations [show details]
… dysregulation in hypothalamic gonadotropin-releasing hormone (GnRH) secretion. The abnormal GnRH secretion characteristic of FHA leads… present for both smokers and nonsmokers . However, this study did not separate women from men. The mechanism for this finding is not known, and further studies are required to confirm this observation. …
5. 成人における発熱の病態生理および治療pathophysiology and treatment of fever in adults [show details]
… the demonstration of other abnormal hypothalamic functions, such as production of hypothalamic releasing factors, abnormal response to cold,… receptor genes leaves the fever mechanism intact. Although PGE2 is essential for fever, PGE2 is not a neurotransmitter. However, release of PGE2 from the brain side…