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1. 小児におけるてんかん症候群epilepsy syndromes in children [show details]
… referred to as myoclonic-atonic epilepsy) are more serious epilepsy disorders in which children always have other seizure types, including tonic and atonic seizures,… infantile spasms, tonic seizures, normal physiologic sleep myoclonus (hypnic jerks), and benign startle responses, among others. Myoclonic seizures in infants can be accompanied by other seizure types, including …
2. 消化管のシャーガス病chagas gastrointestinal disease [show details]
…retention; hypotonic esophagus with weak or absent motor activity; Stage IV (atonic esophagus) – Large increase in volume, atonic, elongated esophagus lying on the right diaphragmatic dome; Esophageal manometry …
3. 経腟分娩後の胎盤遺残と分娩第三期の時間retained placenta after vaginal birth and length of the third stage of labor [show details]
…minimize the occurrence of severe hypotension. Headache is a common side effect. If the uterus is atonic, separation and/or expulsion of the placenta may fail to occur. In these cases, IV infusion of oxytocin …
4. クレアチン代謝の先天性疾患congenital disorders of creatine metabolism [show details]
… Specific seizure types reported include atonic seizures with head drop/nodding, myoclonic seizures, myoclonic astatic seizures (myoclonic followed by atonic),… Measurement of cerebral creatine levels by MRS is used to monitor the therapeutic response and clinical outcomes including muscle weakness,…
5. 国際抗てんかん連盟（ILAE）によるてんかん発作およびてんかんの分類ilae classification of seizures and epilepsy [show details]
…: Febrile seizures plus (can start in infancy) Panayiotopoulos syndrome; Epilepsy with myoclonic atonic (previously astatic) seizures; Benign epilepsy with centrotemporal spikes; Autosomal-dominant nocturnal…

Japanese Journal

過活動膀胱治療薬ミラベグロン創製における薬理研究の貢献

上島浩二,鵜飼政志
日本薬理学雑誌 152(3), 111-118, 2018
… 本邦の3つの研究グループからそれぞれ独立してヒト膀胱平滑筋においてβ3アドレナリン受容体が存在することが報告され，一部の研究グループからはβアドレナリン刺激による膀胱平滑筋弛緩反応において，β3アドレナリン受容体の活性化が主に関与していることが示された．そこで，我々は過活動膀胱治療の新規標的分子として，β3アドレナリン受容体に着目した …
NAID 130007472328