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1. 利尿剤の作用機序mechanism of action of diuretics [show details]
… . Flow-mediated increases in tubular reabsorption distal to the site of action of the diuretic as distal sodium delivery is enhanced . Administration of a loop diuretic, for example, leads to hypertrophy …
2. 心不全患者における利尿剤の使用use of diuretics in patients with heart failure [show details]
… response to a given dose of diuretic than normal subjects for two reasons: decreased diuretic delivery to the kidney (and therefore less transport of diuretic into the tubular lumen) because renal blood …
3. 利尿剤によって誘発された高尿酸血症および痛風diuretic induced hyperuricemia and gout [show details]
… membrane. The diuretic is then released into the tubular fluid from the cell by the urate anion exchanger, OAT4, on the luminal membrane, driving reabsorption of urate. Thiazide diuretics also upregulate …
4. 成人の難治性浮腫の原因と治療causes and treatment of refractory edema in adults [show details]
…cirrhosis (due to renal vasoconstriction), and renal impairment (due to competitive inhibition of tubular diuretic secretion by high concentrations of organic anions that accumulate when the glomerular filtration …
5. 利尿剤誘発性低ナトリウム血症diuretic induced hyponatremia [show details]
… between thiazide and loop diuretics may be related to differences in their tubular site of action : Loop diuretics inhibit sodium chloride (NaCl) reabsorption in the thick ascending limb of the loop of Henle …

Japanese Journal

利尿物質の作用特性とその機構

浦壁重治 [他],白井大祿
日本腎臓学会誌 15(7), 635-644, 1973
… 現在,尿細管性利尿剤の研究はmicropuncture法,clearance法,stop-How法,尿組成分析法などによるnephron作用部位の解明に主として集約されており,その作用機序については種々の推定がなされてはいるが今なお確定的なものはない。 … 最後に以上の成績および従来の成績の総括を試み,さらに細胞膜自体に対する作用の観点から,尿細管性利尿剤の作用特性ならびに作用機構に関する試論を提示した。 …
NAID 130004168033