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- 1. 糸球体の免疫障害の機序mechanisms of immune injury of the glomerulus [show details]
… spontaneous renal disease similar to C3 glomerulopathy . In humans, a familial form of C3 glomerulopathy has been described in patients of Cypriot… and mesangial cells Glomerular endothelial and mesangial cells come into direct contact with circulating…
- 2. 糸球体疾患:成人患者の評価と鑑別診断glomerular disease evaluation and differential diagnosis in adults [show details]
… Glomerular disease can result from many inherited or acquired disorders and can manifest in a variety of ways,… arteriole and supported by a structural matrix called the mesangium, which is maintained by specialized mesangial cells. The glomerular basement membrane (GBM) provides both a size- and charge-selective barrier …
- 3. 住血吸虫症および糸球体疾患schistosomiasis and glomerular disease [show details]
… Patients with progressive schistosomal glomerulopathy frequently have predominant IgA deposits in mesangial,… and genetic factors. Asymptomatic and self-limited glomerular disease may be relatively common in patients with schistosomal infection. Symptomatic patients with schistosomal glomerulopathy most frequently…
- 4. IgA腎症の病因pathogenesis of iga nephropathy [show details]
… binding of IgA to mesangial cell receptor(s) could lead to defective mesangial IgA clearance and thereby contribute to IgA accumulation and the development of glomerular injury.… relatives of patients with familial and sporadic IgA nephropathy, respectively . The heritability of poorly O-galactosylated IgA1 among familial IgA nephropathy cohorts…
- 5. C3糸球体腎症:デンスデポジット病およびC3糸球体腎炎c3 glomerulopathies dense deposit disease and c3 glomerulonephritis [show details]
… There are no characteristic light microscopic findings in C3 glomerulopathy; mesangial proliferative,… complement-mediated glomerular disease . C3GN was first described in 2007 in a clinicopathologic and genetic study of 19 patients . Subsequently, the term "C3 glomerulopathy" was introduced…
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- 腎・尿路疾患のネフローゼ症候群。 今回はその中の巣状分節性糸球体硬化症の説明です。 [巣状分節性糸球体硬化症]focal segmental glomerulosclerosis:FSGS 【概念】 もともと病理組織学的所見に基づく病態...
- 3 ―215― 図1 巣状分節性糸球体硬化症 A:巣状分節状に糸球体硬化病変を認める(PAS染色). B: 糸球体上皮細胞の増生や腫大を認める(PAM染色). 図2 IgA腎症 A :巣状および分節状のメサンギウム細胞増殖と基質の
★リンクテーブル★
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- 英
- glomerulus (Z)
- 関
- ボウマン嚢、腎小体、腎臓、輸出細動脈#調節
概念
- 1個の腎臓に100万個存在。
- 房状の毛細血管からなる
- 糸球体の毛細血管は有窓型毛細血管である
糸球体の微細構造 (SP.785)
詳細には
血流の調節 (HIM.1742)
- 輸入細動脈:autonomous vasoreactive reflex in afferent arteriole, tubuloglomerular feedback
- 緻密斑でのCl-の低下 = 原尿流速が早い → 腎灌流量の低下と解釈
- 腎灌流圧↑→輸入細動脈の平滑筋収縮
- 腎灌流圧↓→輸入細動脈の平滑筋弛緩
- 緻密斑はNaClの再吸収にとともにATP、(アデノシン)を細胞外に放出。細胞外のecto-5'-nucleotidaseがATPからアデノシンを産生。アデノシンが輸入細動脈のvasoconstrictorとして作用
- loop diureticsは緻密斑でのNaClの再吸収を妨げるので、尿細管糸球体フィードバックを阻害→糸球体濾過量は高レベルに保たれる
- アンジオテンシンIIと活性酸素種は尿細管糸球体フィードバックを増強 → 輸入細動脈収縮 → 糸球体濾過量低下
- NOは尿細管糸球体フィードバックを減弱 → 輸入細動脈弛緩 → 糸球体濾過量上昇
- 輸出細動脈:angiotensin II-mediated casoconstriction of the efferent arteiole
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臨床関連
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- 英
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- 関
- 科、家系性、家族性、家庭、系統群、産生、親戚、ファミリ、ファミリー、一対、ファミリーメンバー、家族特性
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- 英
- sis, pathy
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- 英
- lobulation、lobulate、lobation、segmentation
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- familial
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- 家系性、家族