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1. 多発性内分泌腫瘍2型の分類および遺伝学classification and genetics of multiple endocrine neoplasia type 2 [show details]
… with MEN2 is the RET proto-oncogene on chromosome 10. As expected from its autosomal dominant inheritance pattern, males and females with MEN type 2A (MEN2A) are affected… The RET protein is a receptor tyrosine kinase that appears to transduce growth and differentiation signals in several developing tissues,… Activation of RET occurs by the binding of one of its four ligands, glial cell line-derived neurotrophic factor (GDNF), neurturin (TNT), artemin, or persephin, which require their specific co-receptors GDNF-receptor-family-a-1 …
2. びまん性神経膠腫の分子学的発症機序molecular pathogenesis of diffuse gliomas [show details]
… A variety of growth factors, or oncogenes, are amplified and/or overexpressed in high-grade gliomas and thus provide a growth advantage to neoplastic cells.… adult-type and pediatric-type diffuse gliomas have different genetic underpinnings Duplication of the tyrosine kinase domain of the fibroblast growth factor receptor 1 (FGFR1)…
3. 頭頸部の扁平上皮癌化：分子学的および遺伝学的変化head and neck squamous cell carcinogenesis molecular and genetic alterations [show details]
… the epidermal growth factor (EGF)-like ligand binding domain or the NOTCH intracellular domain (NICD). Therapeutically targeting NOTCH-1 in HNSCC is an evolving field. The c-myc oncogene is a potent proliferative …
4. インスリン様成長因子Iの生理学physiology of insulin like growth factor 1 [show details]
… tumor cells for exposure to other growth factors, such as PDGF and epidermal growth factor (EGF) . Certain oncogenes that lead to cellular transformation,… insulin-like growth factor 1 (IGF-1) receptor (sometimes designated type 1 IGF receptor) is the primary mediator of the physiologic actions of IGF-1. The IGF-2/mannose-6-phosphate receptor (type 2 IGF receptor)…
5. 濾胞性リンパ腫の臨床症状、病理学的特徴、診断、および予後clinical manifestations pathologic features diagnosis and prognosis of follicular lymphoma [show details]
… Duodenal-type FL is typically confined to the mucosa, shows at least a partial follicular growth pattern,… a member of the tumor necrosis factor receptor gene family . Pediatric-type FL should be distinguished from the more… elements of the immunoglobulin heavy chain gene (IGH). The resulting overexpression of BCL2, an oncogene that blocks programmed cell death (apoptosis), leads to prolonged cell survival. However, it is …