血漿ハプトグロビン
WordNet
- an amber, watery fluid, rich in proteins, that separates out when blood coagulates (同)blood_serum
- a protein in plasma that binds free hemoglobin and removes it (as from wounds)
PrepTutorEJDIC
- リンパ液 / 血清
- serial / series / sermon
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Immunomodulatory factors and infectious agents associated with the hepatic gene expression of the IGF system in nursery pigs.
- Slifierz MJ1, Friendship R1, de Lange CF2, Slavic D3, Grgic H1, Farzan A1.Author information 11 Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada, N1G 2W1.22 Department of Animal and Poultry Science, University of Guelph, Guelph, ON, Canada, N1G 2W1.33 Animal Health Laboratory, Ontario Veterinary College, University of Guelph, ON, Canada, N1G 2W1.AbstractRecent findings suggest there is a complex interaction between the IGF system and the inflammatory immune response. The objective of this study was to determine whether gene expression of growth factors (IGF-1, IGF-binding protein-3 (IGFBP-3) and growth hormone receptors (GHR)) in the liver is associated with gene expression of immunomodulators in the liver, including C-reactive protein (CRP), serum amyloid A (SAA), haptoglobin (Hp), interferon-α (IFN-α), IFN-γ, tumour necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, IL-10 and IL-18, as well as with the presence of Salmonella spp., Lawsonia intracellularis, Brachyspira spp., enterotoxigenic Escherichia coli, methicillin-resistant Staphylococcus aureus, swine influenza virus, and porcine reproductive and respiratory syndrome virus (PRRSV) in nursery pigs (n=74) from commercial farms (n=4). Gene expression was quantified using reverse transcription quantitative-PCR (RT-qPCR) and the data were modelled using logistic regression methods. Pigs with elevated IGF-1 expression were less likely to have increased expression of TNF-α (odds ratio (OR)=0.14, P<0.01) and IL-18 (OR=0.19, P<0.05), and less likely to be colonized with PRRSV (OR=0.03, P<0.01). Pigs with increased expression of IGFBP-3 were more likely to have elevated IL-6 expression (OR=8.5, P<0.05). It was also observed that IGFBP-3 and IGF-1 were significantly associated when Hp expression was low (OR=30, P<0.05), but this association was not significant when Hp expression was high (P=0.54). Pigs with increased expression of GHR were less likely to have elevated expression of SAA (OR=0.01, P<0.05) and IL-1β (OR=0.03, P<0.05), but more likely to have increased expression of CRP (OR=290, P<0.01). Overall, there appears to be an inverse association between the hepatic expression of the IGF system (IGF-1, IGFBP-3, GHR) and certain cytokines (IL-1β, IL-18, TNF-α) and acute-phase proteins (SAA, Hp).
- Animal : an international journal of animal bioscience.Animal.2014 May;8(5):844-51. doi: 10.1017/S1751731114000275. Epub 2014 Feb 27.
- Recent findings suggest there is a complex interaction between the IGF system and the inflammatory immune response. The objective of this study was to determine whether gene expression of growth factors (IGF-1, IGF-binding protein-3 (IGFBP-3) and growth hormone receptors (GHR)) in the liver is assoc
- PMID 24576503
- Identification and validation of novel candidate protein biomarkers for the detection of human gastric cancer.
- Humphries JM1, Penno MA2, Weiland F3, Klingler-Hoffmann M4, Zuber A5, Boussioutas A6, Ernst M7, Hoffmann P8.Author information 1Adelaide Proteomics Centre, School of Molecular Biomedical Science, The University of Adelaide, Adelaide, SA 5005, Australia. Electronic address: julia.humphries@health.sa.gov.au.2Adelaide Proteomics Centre, School of Molecular Biomedical Science, The University of Adelaide, Adelaide, SA 5005, Australia. Electronic address: megan.penno@adelaide.edu.au.3Adelaide Proteomics Centre, School of Molecular Biomedical Science, The University of Adelaide, Adelaide, SA 5005, Australia. Electronic address: florian.weiland@adelaide.edu.au.4Adelaide Proteomics Centre, School of Molecular Biomedical Science, The University of Adelaide, Adelaide, SA 5005, Australia. Electronic address: manuela.klinglerhoffmann@adelaide.edu.au.5Institute for Photonics & Advanced Sensing, The University of Adelaide, Adelaide, SA 5005, Australia. Electronic address: agnieszka.zuber@adelaide.edu.au.6Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC 3050, Australia; Cancer Genomics and Predictive Medicine, Peter MacCallum Cancer Centre, East Melbourne, VIC 8006, Australia.7Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.8Adelaide Proteomics Centre, School of Molecular Biomedical Science, The University of Adelaide, Adelaide, SA 5005, Australia. Electronic address: peter.hoffmann@adelaide.edu.au.AbstractThe timely detection of gastric cancer will contribute significantly towards effective treatment and is aided by the availability and reliability of appropriate biomarkers. A combination of several biomarkers can improve the sensitivity and specificity of cancer detection and this work reports results from a panel of 4 proteins. By combining a validated preclinical mouse model with a proteomic approach we have recently discovered novel biomarkers for the detection of gastric cancer. Here, we investigate the specificity of four of those biomarkers (afamin, clusterin, VDBP and haptoglobin) for the detection of gastric cancer using two independent methods of validation: ELISA, and a non antibody based method: Multiple Reaction Monitoring with High Resolution Mass Spectrometry (MRM-HR). All four biomarkers reliably differentiated GC from benign patient serum, and also in a small cohort of 11 early stage cases. We also present a novel isoform specific biomarker alpha-1-antitrypsin (A1AT) that was identified using a mouse model for gastric cancer. This isoform is distinct in charge and mobility in a pH gradient and was validated using human samples by isoelectric focussing and Western-blot (IEF-WB). This article is part of a Special Issue entitled: Biomarkers: A Proteomic Challenge.
- Biochimica et biophysica acta.Biochim Biophys Acta.2014 May;1844(5):1051-8. doi: 10.1016/j.bbapap.2014.01.018. Epub 2014 Feb 7.
- The timely detection of gastric cancer will contribute significantly towards effective treatment and is aided by the availability and reliability of appropriate biomarkers. A combination of several biomarkers can improve the sensitivity and specificity of cancer detection and this work reports resul
- PMID 24512919
- The effect of exercise on plasma concentrations of inflammatory markers in normal and previously laminitic ponies.
- Menzies-Gow NJ1, Wray H, Bailey SR, Harris PA, Elliott J.Author information 1Royal Veterinary College, London, UK.AbstractREASONS FOR PERFORMING STUDY: The mechanisms underlying predisposition to pasture-associated laminitis remain unclear; chronic inflammation is implicated, and this may be exacerbated by physical inactivity.
- Equine veterinary journal.Equine Vet J.2014 May;46(3):317-21. doi: 10.1111/evj.12132. Epub 2013 Sep 11.
- REASONS FOR PERFORMING STUDY: The mechanisms underlying predisposition to pasture-associated laminitis remain unclear; chronic inflammation is implicated, and this may be exacerbated by physical inactivity.OBJECTIVES: To determine whether exercise affects the inflammatory profile of normal and previ
- PMID 23819851
Japanese Journal
- 内視鏡的食道静脈瘤硬化療法後の血清コリンエステラーゼ活性上昇に関する検討
- 仲地 健一郎,曽 絵里子,大久保 政雄,小林 克也,松川 雅也,関川 憲一郎,松浦 広,光井 洋,山口 肇,西村 恵理子,小林 照明,橋本 直明
- 肝臓 52(12), 784-786, 2011-12-25
- NAID 10030240701
- 第37回家畜診療等技術全国研究集会・入賞論文 全国農業共済協会長賞 牛急性疾患の診断における簡易ラテックス試験法を用いた血清ハプトグロビン濃度測定の有用性
★リンクテーブル★
[★]
- 英
- serum haptoglobin
- 関
- ハプトグロビン